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Yeast Fitness
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YIL120W / QDR1



Section 1: Phenotypes.
Gene-drug relationships for YIL120W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YIL120W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for QDR1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 4.53503 0.0030984
itraconazole 8.8 uM 4.17841 6.3239e-05
methotrexate 125 uM 4.1189 0.00012524
thiram 15.6 uM 3.98102 0.00011825
no drug minimal media 0 3.97425 0.0036656
vitamin k3 15.63 uM 3.87632 0.00024756
no drug minimal media 0 3.84936 0.0060045
telomerase inhibitor ix (Biomol) 500 uM 3.84493 0.00027017
fenpropimorph 1.2 uM 3.69844 0.00028348
5-fluorocytosine 15.6 uM 3.65234 0.00032608

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for QDR1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
nocodazole 10 ug/ml 8.19725 8.647e-08
licl 150 mM 5.52691 1.7748e-06
licl 150 mM 5.18038 5.0105e-06
mechlorethamine 62.5 uM 4.65872 4.1373e-05
synthetic complete for BY4743 0 4.10101 0.013117
licl 100 mM 4.06485 0.00036346
zncl2 1875 uM 3.75464 0.00032513
cisplatin 31.25 uM 3.54478 0.00075678
nocodazole 10 ug/ml 3.49702 0.0012869
ph4 8 3.3339 0.0010387

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YIL120W

Top 10 functional gene interactors with YIL120W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with QDR1 by heterozygous co-sensitivity:

Query Interactor Correlation
QDR1 YBR074W_p 0.3845
QDR1 ICS2 0.35481
QDR1 DIC1 0.353
QDR1 YBR259W 0.33735
QDR1 FMP51 0.33562
QDR1 CSN12 0.33122
QDR1 SSB1 0.33044
QDR1 SAM2 0.32993
QDR1 EDS1 0.32556
QDR1 RHR2 0.32152

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with QDR1 by homozygous co-sensitivity:

Query Interactor Correlation
QDR1 ZRG17 0.68099
QDR1 TIP1 0.59329
QDR1 GAL7 0.57367
QDR1 YRO2 0.5524
QDR1 PRM5 0.5486
QDR1 YNL122C 0.54382
QDR1 SCO2 0.53736
QDR1 FMP23 0.53582
QDR1 YIL100W 0.53196
QDR1 ZTA1 0.53142

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YIL120W

Other databases:

Visit YIL120W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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