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Yeast Fitness

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YIL021W / RPB3

Section 1: Phenotypes.
Gene-drug relationships for YIL021W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YIL021W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPB3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
fenpropimorph 1.65 nM 7.60108 0.00031301
dyclonine 500 uM 4.24884 0.00056481
progesterone 1000 uM 4.12358 0.004571
novobiocin 1000 uM 4.12038 0.00012472
juglone 200 uM 3.78927 0.00031532
latrunculin 3.91 uM 3.55669 0.00059714
chemdiv 41 500 uM 3.54509 0.00061626
wiskostatin 29 uM 3.54005 0.00062475
phosphatase inhibitor 100 uM 3.48334 0.00072843
dihydromotuporamine C 15 uM 3.41974 0.00086444

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YIL021W

Top 10 functional gene interactors with YIL021W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with RPB3 by heterozygous co-sensitivity:

Query Interactor Correlation
RPB3 RPO26 0.57348
RPB3 RPB4 0.56109
RPB3 RPB7 0.54361
RPB3 RPB9 0.48353
RPB3 DIA1 0.39401
RPB3 SEC4 0.38965
RPB3 CCT7 0.38645
RPB3 RPB8 0.38223
RPB3 RPB11 0.38176
RPB3 ATC1 0.37803

More... (click to see all interactions)

Enriched GO terms of interactors

Homozygous co-fitness interactions

[No homozygous results.]

External information about YIL021W

Other databases:

Visit YIL021W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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