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YIL020C / HIS6



Section 1: Phenotypes.
Gene-drug relationships for YIL020C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YIL020C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for HIS6 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
dna protein kinase inhibitor 0 7.72828 4.1114e-09
dihydromotuporamine C 15 uM 6.99414 3.1615e-08
mitomycin c 1000 uM 6.845 7.0255e-09
nacl 700 mM 6.19573 3.0833e-07
itraconazole 4.4 uM 5.80126 2.6867e-07
itraconazole 17.7 uM 5.76539 3.043e-07
methotrexate 500 uM 5.5408 2.0587e-06
methotrexate 500 uM 5.18234 5.8458e-06
itraconazole 17.7 uM 5.08302 3.1749e-06
methotrexate 500 uM 4.76451 1.9676e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for HIS6 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mncl2 2 mM 11.72 < 1e-12
mitomycin c 1000 uM 9.55283 1.8573e-11
mechlorethamine 62.5 uM 7.97114 0.0076882
mncl2 1 mM 5.98089 4.5592e-07
mncl2 1 mM 5.82548 7.2566e-07
licl 150 mM 5.17553 5.0838e-06
licl 150 mM 5.10205 6.3328e-06
sorbitol 1.5e+06 uM 4.87188 2.3563e-05
mechlorethamine 62.5 uM 4.46111 0.010487
synthetic complete for BY4743 0 4.10348 0.027286

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YIL020C

Top 10 functional gene interactors with YIL020C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with HIS6 by heterozygous co-sensitivity:

Query Interactor Correlation
HIS6 CMP2 0.43546
HIS6 ZEO1 0.43481
HIS6 BRE2 0.42823
HIS6 PGM2 0.41281
HIS6 PRM1 0.40911
HIS6 RBD2 0.40898
HIS6 SMA2 0.39925
HIS6 YER067W 0.39828
HIS6 PAU8 0.39534
HIS6 PRY1 0.39191

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with HIS6 by homozygous co-sensitivity:

Query Interactor Correlation
HIS6 YJL135W 0.55923
HIS6 COX5B 0.53801
HIS6 LAG2 0.53654
HIS6 LPP1 0.5063
HIS6 YMR087W 0.50006
HIS6 CUP9 0.48805
HIS6 YOL048C 0.48786
HIS6 CNA1 0.48403
HIS6 FRE1 0.48401
HIS6 YIL057C 0.47181

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YIL020C

Other databases:

Visit YIL020C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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