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Yeast Fitness

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YHR190W / ERG9

Section 1: Phenotypes.
Gene-drug relationships for YHR190W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YHR190W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ERG9 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 9.83594 1.6964e-11
methotrexate 500 uM 9.38584 5.2211e-11
methotrexate 500 uM 8.20812 1.1208e-09
alverine citrate 500 uM 8.05485 0.0075327
alverine citrate 500 uM 7.12894 0.0095571
acriflavinium hydrochloride 250 uM 5.59075 5.5712e-07
miconazole 0.2 uM 4.57989 0.00015413
alverine citrate 500 uM 4.39161 0.00043911
bufexamac 1000 uM 3.77433 0.00022476
bufexamac 1000 uM 3.76456 0.00023161

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YHR190W

Top 10 functional gene interactors with YHR190W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with ERG9 by heterozygous co-sensitivity:

Query Interactor Correlation
ERG9 RSM27 0.52468
ERG9 RRN5 0.44848
ERG9 ALG14 0.44745
ERG9 ZPR1 0.43773
ERG9 RMP1 0.43559
ERG9 ZUO1 0.43159
ERG9 TAF11 0.43076
ERG9 YHC1 0.43025
ERG9 ATP11 0.42459
ERG9 PRP2 0.42377

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YHR190W

Other databases:

Visit YHR190W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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