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Yeast Fitness
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YHR186C / KOG1



Section 1: Phenotypes.
Gene-drug relationships for YHR186C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YHR186C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for KOG1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
miconazole 0.2 uM 17.2345 4.6824e-12
ketoconazole 11.8 uM 15.6045 2.1094e-11
wortmannin 50 uM 12.0228 < 1e-12
dyclonine 500 uM 9.89469 2.0074e-07
tunicamycin 0.15 uM 9.6546 2.2348e-08
alverine citrate 500 uM 7.33097 0.0090516
alverine citrate 500 uM 7.1675 5.6823e-06
nocodazole 2 ug/ml 7.12953 2.6021e-09
rapamycin 9 nM 6.43884 1.5328e-07
paraquat 2000 uM 6.39169 1.7547e-07

More... (click to see all Heterozygous data)

 
Homozygous knockout:

[No Homozygous results.]




Section 2: Co-fitness interactions.
Gene-gene relationships for YHR186C

Top 10 functional gene interactors with YHR186C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with KOG1 by heterozygous co-sensitivity:

Query Interactor Correlation
KOG1 SEC2 0.39952
KOG1 SEC10 0.3951
KOG1 RBA50 0.39182
KOG1 ARC40 0.39109
KOG1 ZPR1 0.38324
KOG1 STT4 0.37913
KOG1 YSH1 0.37698
KOG1 ERG9 0.37386
KOG1 YHC1 0.37125
KOG1 TCO89 0.36623

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YHR186C

Other databases:

Visit YHR186C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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