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YHR148W / IMP3

Section 1: Phenotypes.
Gene-drug relationships for YHR148W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YHR148W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for IMP3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
haloperidol 125 uM 4.86178 6.7013e-06
fenpropimorph 4.7 uM 4.50403 2.1996e-05
drofenine hydrochloride 750 uM 4.29372 4.3644e-05
dyclonine 500 uM 3.36597 0.00076387
k2cr2o7 6.25 uM 3.31653 0.0011386
filipin 100 uM 3.29691 0.0011994
zaluzanin c 1000 uM 3.06265 0.002212
methotrexate 250 uM 3.04704 0.0023025
amphotericin b 0.62 uM 2.87726 0.0030078
distamycin a 250 uM 2.83372 0.0039509

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YHR148W

Top 10 functional gene interactors with YHR148W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with IMP3 by heterozygous co-sensitivity:

Query Interactor Correlation
IMP3 BUB1 0.58545
IMP3 YPR136C 0.56491
IMP3 RRP9 0.5554
IMP3 RPS29B 0.5471
IMP3 RPS9B 0.54486
IMP3 RPS1B 0.52974
IMP3 UTP13 0.52888
IMP3 UTP18 0.52857
IMP3 UTP8 0.52565
IMP3 RPS23B 0.51606

More... (click to see all interactions)

Enriched GO terms of interactors

Homozygous co-fitness interactions

[No homozygous results.]

External information about YHR148W

Other databases:

Visit YHR148W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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