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Yeast Fitness
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YHR106W / TRR2



Section 1: Phenotypes.
Gene-drug relationships for YHR106W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YHR106W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for TRR2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
miconazole 0.2 uM 5.54305 2.2274e-05
floxuridine 3.37 uM 3.75282 0.0008687
allyl disulfide 0.06 % 3.65378 0.00045809
progesterone 1000 uM 3.63705 0.0074748
tunicamycin 0.15 uM 3.26654 0.011142
5-fluorouracil 38.5 uM 3.25102 0.0025051
allyl sulfide 0.12 % 3.13695 0.0018251
wiskostatin 29 uM 3.1266 0.0018749
methotrexate 500 uM 3.09855 0.0020162
norcantharidin 2500 uM 3.03176 0.0023946

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for TRR2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 0.78 uM 5.59985 0.01522
latrunculin 0.78 uM 4.31756 0.02484
latrunculin 0.78 uM 4.13662 0.012821
mitomycin c 1000 uM 4.07761 0.00012954
synthetic complete for BY4743 0 3.66757 0.00724
latrunculin 0.78 uM 2.88977 0.0048793
5-fluorouracil 19.2 uM 2.4686 0.016592
allyl disulfide 0.06 % 2.46584 0.0094359
mncl2 2 mM 2.34033 0.012636
synthetic complete for BY4743 0 2.2681 0.075719

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YHR106W

Top 10 functional gene interactors with YHR106W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with TRR2 by heterozygous co-sensitivity:

Query Interactor Correlation
TRR2 STE13 0.85188
TRR2 ASI1 0.84518
TRR2 YPL197C 0.823
TRR2 DIT2 0.82164
TRR2 YKL171W 0.80952
TRR2 YOL013W-A 0.80916
TRR2 YDL094C 0.80812
TRR2 YOL083W 0.79101
TRR2 YDR157W 0.79045
TRR2 RSB1 0.78166

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with TRR2 by homozygous co-sensitivity:

Query Interactor Correlation
TRR2 YNL155W 0.54027
TRR2 MLH2 0.52357
TRR2 YHR035W 0.52308
TRR2 PXA1 0.51571
TRR2 BNA1 0.51001
TRR2 GAT3 0.50079
TRR2 HAL1 0.50069
TRR2 YLL059C 0.49551
TRR2 YML002W 0.49389
TRR2 FMS1 0.48559

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YHR106W

Other databases:

Visit YHR106W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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