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YHR094C / HXT1



Section 1: Phenotypes.
Gene-drug relationships for YHR094C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YHR094C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for HXT1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
tryptanthrin 250 uM 4.05829 0.00014862
sanguinarine sulfate 250 uM 2.87835 0.002999
ID 622648 31.25 uM 2.71211 0.0053335
cantharidin 250 uM 2.71076 0.056701
fluconazole 130.6 uM 2.4786 0.0084181
cantharidin 250 uM 2.40944 0.06879
caspofungin 10 nM 2.25037 0.014572
sodium sulfate 625 uM 2.24603 0.015868
cantharidin 250 uM 2.18647 0.080166
cyclamin 62.5 uM 2.14012 0.020034

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for HXT1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 15.2664 0.00030518
synthetic complete for BY4743 0 8.77151 0.0063746
ph4 8 5.49795 1.9357e-06
ph4 8 5.02393 7.9969e-06
mncl2 2 mM 3.45742 0.0007423
paraquat 5000 uM 3.19953 0.0014888
mechlorethamine 62.5 uM 3.17195 0.043333
sorbitol 1 M 2.93129 0.0029987
nocodazole 10 ug/ml 2.90631 0.0047081
acetic acid 50 uM 2.80183 0.0041635

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YHR094C

Top 10 functional gene interactors with YHR094C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with HXT1 by heterozygous co-sensitivity:

Query Interactor Correlation
HXT1 SHC1 0.4277
HXT1 GOT1 0.41716
HXT1 HMF1 0.41175
HXT1 YHR095W 0.40808
HXT1 IME1 0.40672
HXT1 YTA6 0.39643
HXT1 GLR1 0.39423
HXT1 YOR066W 0.39375
HXT1 ARG1 0.38762
HXT1 NTG1 0.38646

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with HXT1 by homozygous co-sensitivity:

Query Interactor Correlation
HXT1 ATG9 0.58698
HXT1 YJL068C 0.55453
HXT1 HXT2 0.54148
HXT1 YJL038C 0.53192
HXT1 YMR252C 0.5242
HXT1 YOL092W 0.52257
HXT1 MCH5 0.52199
HXT1 YLR456W 0.5202
HXT1 SPO71 0.51119
HXT1 ADE17 0.50668

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None




External information about YHR094C

Other databases:

Visit YHR094C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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