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Yeast Fitness
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YHR093W / AHT1



Section 1: Phenotypes.
Gene-drug relationships for YHR093W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YHR093W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for AHT1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 28.4551 < 1e-12
miconazole 0.2 uM 14.2854 7.9255e-11
5-fluorouracil 38.5 uM 7.86151 2.0677e-10
telomerase inhibitor ix (Biomol) 500 uM 7.18129 1.8693e-08
caspofungin 10 nM 5.00969 4.0705e-06
caspofungin 10 nM 5.00233 4.1731e-06
nacl 700 mM 4.97432 1.0706e-05
caspofungin 10 nM 4.56863 1.7783e-05
methotrexate 500 uM 3.47882 0.00073737
lapachol 500 uM 3.40226 0.000687

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for AHT1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mms 0.002 % 6.86636 0.010279
mechlorethamine 62.5 uM 5.09236 0.018233
mycophenolic acid 125 uM 2.92884 0.0034951
angelicin 62.5 uM 2.7256 0.0069377
23 degrees C 0 2.42171 0.013458
mechlorethamine 62.5 uM 2.2932 0.052823
zncl2 1875 uM 1.96911 0.028567
synthetic complete for BY4743 0 1.95035 0.04606
carboplatin 700 uM 1.83853 0.041272
bisphenol 125 uM 1.82891 0.042015

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YHR093W

Top 10 functional gene interactors with YHR093W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with AHT1 by heterozygous co-sensitivity:

Query Interactor Correlation
AHT1 AHA1 0.68039
AHT1 SSO1 0.65832
AHT1 CWP1 0.65577
AHT1 ERP5 0.65044
AHT1 YCR090C 0.64414
AHT1 YKL187C 0.62957
AHT1 MET14 0.62945
AHT1 YMR111C 0.62867
AHT1 CYC1 0.62604
AHT1 CHZ1 0.62201

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with AHT1 by homozygous co-sensitivity:

Query Interactor Correlation
AHT1 FMS1 0.93038
AHT1 YCR090C 0.9081
AHT1 ALK1 0.86805
AHT1 RNP1 0.86524
AHT1 PXA1 0.86314
AHT1 FSH1 0.86244
AHT1 YER186C 0.84772
AHT1 YHR126C 0.83008
AHT1 DBP1 0.82938
AHT1 SPH1 0.82887

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YHR093W

Other databases:

Visit YHR093W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None

Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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