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Yeast Fitness
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YHR077C / NMD2



Section 1: Phenotypes.
Gene-drug relationships for YHR077C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YHR077C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for NMD2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 19.4958 < 1e-12
methotrexate 500 uM 9.0003 1.3968e-10
methotrexate 500 uM 8.35305 7.6116e-10
methotrexate 250 uM 5.72375 1.2093e-06
lawsone 500 uM 4.27132 8.1241e-05
resveratrol 2000 uM 4.02046 0.00016533
fk506 0.05 ug/ml 3.85827 0.00026033
latrunculin 3.91 uM 3.65968 0.00045073
latrunculin 1.95 uM 3.59052 0.00054458
splitomicin 250 uM 3.53902 0.0006265

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for NMD2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 21.7945 4.6252e-10
synthetic complete for BY4743 0 19.2985 1.5209e-09
mms 0.002 % 18.585 0.0014413
synthetic complete for BY4743 0 16.4142 0.0018455
nacl 1000 uM 15.2397 1.501e-08
nacl 1000 uM 13.6711 4.2487e-08
cadmium chloride 7.81 uM 12.2278 < 1e-12
methotrexate 250 uM 11.7659 3.239e-12
k2cr2o7 125 uM 11.4462 < 1e-12
licl 100 mM 10.8939 1.1773e-09

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YHR077C

Top 10 functional gene interactors with YHR077C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with NMD2 by heterozygous co-sensitivity:

Query Interactor Correlation
NMD2 YLR326W 0.53792
NMD2 YER039C-A 0.51766
NMD2 YJR038C 0.51352
NMD2 CSI1 0.49147
NMD2 SSO1 0.48864
NMD2 APM4 0.48724
NMD2 FMP46 0.48662
NMD2 GDH1 0.48512
NMD2 THI21 0.48104
NMD2 YBL055C 0.47387

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with NMD2 by homozygous co-sensitivity:

Query Interactor Correlation
NMD2 UPF3 0.83198
NMD2 NMD4 0.66403
NMD2 FMP14 0.57136
NMD2 YPR064W 0.56865
NMD2 NHP6A 0.52114
NMD2 NAM7 0.50957
NMD2 MND2 0.46454
NMD2 ROX1 0.43979
NMD2 ATG29 0.43425
NMD2 MDS3 0.42732

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:




External information about YHR077C

Other databases:

Visit YHR077C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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