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YHR051W / COX6



Section 1: Phenotypes.
Gene-drug relationships for YHR051W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YHR051W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for COX6 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 3.91 uM 9.09197 1.1034e-10
tryptanthrin 250 uM 7.7474 3.9019e-09
alverine citrate 500 uM 5.95143 0.013546
licl 150 mM 4.657 2.685e-05
nerol 1000 uM 3.7264 0.00037517
miconazole 50 nM 3.692 0.0015403
alverine citrate 500 uM 3.62998 0.034109
resveratrol 2000 uM 3.52499 0.00065079
licl 150 mM 3.46345 0.00076857
paraquat 2000 uM 3.43989 0.0008189

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for COX6 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
rapamycin 9 nM 21.612 0.0010671
latrunculin 0.78 uM 13.168 0.0028588
synthetic complete for BY4743 0 12.2413 0.00058698
potassium disulfite 2500 uM 8.71934 3.5201e-08
rapamycin 9 nM 5.33793 0.0064269
latrunculin 0.78 uM 5.08515 0.0073476
synthetic complete for BY4743 0 3.4612 0.0052653
nocodazole 10 ug/ml 3.27384 0.0021089
rapamycin 9 nM 2.30634 0.073753
ro 106-9920 (Calbio) 125 uM 2.155 0.019166

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YHR051W

Top 10 functional gene interactors with YHR051W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with COX6 by heterozygous co-sensitivity:

Query Interactor Correlation
COX6 GEM1 0.53611
COX6 RIB2 0.5126
COX6 NPT1 0.49767
COX6 VPS33 0.48066
COX6 SAM35 0.47962
COX6 YGL072C 0.47359
COX6 IES3 0.47209
COX6 MDM10 0.47094
COX6 DYS1 0.46457
COX6 YCR064C 0.4561

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
 
Homozygous co-fitness interactions

Top 10 interactors with COX6 by homozygous co-sensitivity:

Query Interactor Correlation
COX6 YDL119C 0.43012
COX6 MDM35 0.38793
COX6 YPL062W 0.38615
COX6 LSM6 0.3809
COX6 YMR098C 0.37975
COX6 YME1 0.37465
COX6 UPS1 0.37132
COX6 HTD2 0.35826
COX6 ABF2 0.35717
COX6 YNR036C 0.34741

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YHR051W

Other databases:

Visit YHR051W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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