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Yeast Fitness
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YHR013C / ARD1



Section 1: Phenotypes.
Gene-drug relationships for YHR013C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YHR013C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ARD1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mechlorethamine 500 uM 9.5405 2.3391e-12
licl 150 mM 7.43561 9.2063e-09
cloxyquin 15.6 uM 5.73141 3.4237e-07
clozapine 125 uM 5.57919 5.7982e-07
fk506 0.1 ug/ml 5.19487 5.6366e-06
fk506 0.1 ug/ml 4.63356 2.8731e-05
econazole nitrate 0.24 uM 4.21187 5.6808e-05
itraconazole 17.7 uM 4.05892 9.2499e-05
trichlormethine 1000 uM 3.95873 0.00012682
progesterone 250 uM 3.62545 0.0003537

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for ARD1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 39.5857 < 1e-12
rapamycin 9 nM 30.4274 0.00053918
rapamycin 9 nM 17.1949 0.00021428
nocodazole 10 ug/ml 8.73235 3.4437e-08
rapamycin 9 nM 7.93636 0.0077541
nocodazole 10 ug/ml 7.04872 7.0772e-07
2-cyanoethyl acrylate 360000 uM 5.73298 9.7807e-06
synthetic complete for BY4743 0 5.19678 0.0069211
angelicin 62.5 uM 3.67832 0.00085985
mms 0.002 % 3.6251 0.034191

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YHR013C

Top 10 functional gene interactors with YHR013C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ARD1 by heterozygous co-sensitivity:

Query Interactor Correlation
ARD1 RNA1 0.70273
ARD1 URB1 0.69538
ARD1 BUD16 0.6934
ARD1 PGA3 0.69236
ARD1 TKL2 0.68417
ARD1 YCR064C 0.68183
ARD1 PCM1 0.67997
ARD1 YJL032W 0.67497
ARD1 LTV1 0.6704
ARD1 RIB2 0.66923

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with ARD1 by homozygous co-sensitivity:

Query Interactor Correlation
ARD1 IMG1 0.60416
ARD1 PDA1 0.56481
ARD1 COR1 0.55915
ARD1 YER087W 0.52909
ARD1 IKI3 0.52597
ARD1 MRP20 0.52334
ARD1 YBL081W 0.52063
ARD1 BUD21 0.51744
ARD1 SLX8 0.49689
ARD1 AEP2 0.48983

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:




External information about YHR013C

Other databases:

Visit YHR013C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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