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YHR007C / ERG11

Section 1: Phenotypes.
Gene-drug relationships for YHR007C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YHR007C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ERG11 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
itraconazole 4.4 uM 20.961 < 1e-12
itraconazole 8.8 uM 19.5997 < 1e-12
econazole nitrate 0.24 uM 18.8183 < 1e-12
itraconazole 4.4 uM 18.7282 < 1e-12
itraconazole 8.8 uM 18.5806 < 1e-12
itraconazole 8.8 uM 18.287 < 1e-12
itraconazole 4.4 uM 18.1008 < 1e-12
itraconazole 8.8 uM 18.0284 < 1e-12
clotrimazole 2 uM 17.9732 < 1e-12
itraconazole 2.2 uM 17.9387 < 1e-12

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YHR007C

Top 10 functional gene interactors with YHR007C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with ERG11 by heterozygous co-sensitivity:

Query Interactor Correlation
ERG11 NCP1 0.58221
ERG11 PDR16 0.57874
ERG11 PDR5 0.49733
ERG11 HFI1 0.48602
ERG11 YDR290W 0.47525
ERG11 SET6 0.4739
ERG11 YOR333C 0.47085
ERG11 YGL199C 0.46448
ERG11 YOR331C 0.45266
ERG11 YOR379C 0.44861

More... (click to see all interactions)

Enriched GO terms of interactors

Homozygous co-fitness interactions

[No homozygous results.]

External information about YHR007C

Other databases:

Visit YHR007C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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