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Yeast Fitness
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YHL032C / GUT1



Section 1: Phenotypes.
Gene-drug relationships for YHL032C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YHL032C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for GUT1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
miconazole 0.2 uM 9.26863 3.909e-08
thiabendazole 250 uM 7.18509 2.1441e-09
wiskostatin 29 uM 6.07313 4.3926e-07
clotrimazole 1 uM 5.12642 2.7396e-06
miconazole 25 nM 5.10103 2.9865e-06
methotrexate 500 uM 4.82846 0.0023815
metergoline 250 uM 4.64765 1.3693e-05
trichostatin A 3.91 uM 4.17667 0.00010633
latrunculin 6.25 uM 4.16071 0.00036831
atorvastatin 125 uM 3.70137 0.00028096

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for GUT1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 19.7952 0.00014086
mms 0.002 % 7.87872 0.0078653
mncl2 2 mM 7.64471 3.4687e-09
wiskostatin 29 uM 6.24254 2.0891e-07
latrunculin 3 uM 4.85565 6.3506e-05
lovastatin 154.5 uM 4.61181 4.6828e-05
cisplatin 125 uM 4.27141 0.00011484
mncl2 1 mM 4.11082 0.00011771
licl 150 mM 3.92361 0.00020143
thimerosal 125 nM 3.9106 0.00051246

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YHL032C

Top 10 functional gene interactors with YHL032C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with GUT1 by heterozygous co-sensitivity:

Query Interactor Correlation
GUT1 FMP12 0.59586
GUT1 YOR022C 0.58944
GUT1 FCY22 0.57421
GUT1 ECM34 0.57071
GUT1 COS1 0.54593
GUT1 OCA5 0.5448
GUT1 YHL037C 0.54128
GUT1 ARF3 0.54033
GUT1 HVG1 0.53977
GUT1 RRM3 0.53834

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with GUT1 by homozygous co-sensitivity:

Query Interactor Correlation
GUT1 YHR033W 0.63416
GUT1 MHT1 0.61368
GUT1 YMR178W 0.59391
GUT1 YER135C 0.5749
GUT1 EAF5 0.57384
GUT1 GEA1 0.56417
GUT1 JEN1 0.5634
GUT1 YIR042C 0.56252
GUT1 AYT1 0.55866
GUT1 YOR059C 0.55459

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YHL032C

Other databases:

Visit YHL032C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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