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Yeast Fitness
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YGR248W / SOL4



Section 1: Phenotypes.
Gene-drug relationships for YGR248W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGR248W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SOL4 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 3.30343 0.010697
ID 652287 500 uM 3.26087 0.0013193
bay 11-7082 12.5 uM 3.14877 0.0017699
phloretin 500 uM 2.71876 0.0052475
4-isopropyltropolone 15.63 uM 2.50533 0.0087584
no drug minimal media 0 2.50373 0.023147
wiskostatin 19 uM 2.45215 0.0099196
borrelidin 15.63 uM 2.31628 0.013552
indirubin 100 uM 2.30216 0.013991
chemdiv 246 62 uM 2.17442 0.018589

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for SOL4 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 9.09134 0.0014059
fk506 0.05 ug/ml 6.02557 3.9895e-07
methotrexate 250 uM 5.43645 5.3306e-06
mechlorethamine 62.5 uM 4.91784 0.019474
zncl2 1875 uM 4.33134 6.2039e-05
carboplatin 15 mM 4.27867 0.00022599
methotrexate 250 uM 3.86558 0.00033158
nitric oxide 800 uM 3.85792 0.00033823
methotrexate 500 uM 3.8392 0.00060085
nocodazole 10 ug/ml 3.80332 0.00065086

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YGR248W

Top 10 functional gene interactors with YGR248W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SOL4 by heterozygous co-sensitivity:

Query Interactor Correlation
SOL4 PXA2 0.8109
SOL4 YGR130C 0.77013
SOL4 YJL007C 0.76565
SOL4 YMR041C 0.76479
SOL4 PPR1 0.75931
SOL4 YAL027W 0.7524
SOL4 SVS1 0.73733
SOL4 AGX1 0.73418
SOL4 YBL048W 0.73373
SOL4 ALG5 0.72952

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with SOL4 by homozygous co-sensitivity:

Query Interactor Correlation
SOL4 PET10 0.56481
SOL4 PTH2 0.54528
SOL4 PAU13 0.50695
SOL4 NCE102 0.504
SOL4 TMA17 0.4996
SOL4 YCL076W 0.4771
SOL4 CPT1 0.46935
SOL4 YLR112W 0.46699
SOL4 CRC1 0.45568
SOL4 YEH1 0.45118

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YGR248W

Other databases:

Visit YGR248W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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