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Yeast Fitness

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YGR246C / BRF1

Section 1: Phenotypes.
Gene-drug relationships for YGR246C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGR246C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for BRF1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 3.83831 0.00027519
methotrexate 500 uM 3.5744 0.00056904
psoralen 62.5 uM 3.16506 0.0016963
methotrexate 500 uM 2.82759 0.0040117
cantharidin 250 uM 2.78147 0.054302
fluconazole 65.3 uM 2.54868 0.0070695
dyclonine 500 uM 2.5002 0.013953
lovastatin 154.5 uM 2.44348 0.0091781
nocodazole 6.9 uM 2.37217 0.031891
benomyl 6.9 uM 2.25864 0.036739

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YGR246C

Top 10 functional gene interactors with YGR246C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with BRF1 by heterozygous co-sensitivity:

Query Interactor Correlation
BRF1 SFT1 0.69666
BRF1 UME6 0.68751
BRF1 POP8 0.64089
BRF1 PRI2 0.60606
BRF1 MRPL38 0.59667
BRF1 BUD26 0.59489
BRF1 RAD54 0.58722
BRF1 ULP1 0.57086
BRF1 RPL1B 0.56234
BRF1 DUO1 0.56044

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YGR246C

Other databases:

Visit YGR246C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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