Retrieving results for YGR239C, please wait...

Yeast Fitness
Database

Quick Search

Enter orf / gene / drug:

(e.g. pex22 or lovastatin)  
Advanced search

YGR239C / PEX21



Section 1: Phenotypes.
Gene-drug relationships for YGR239C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGR239C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for PEX21 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
lapachol 500 uM 6.17094 7.4142e-08
dna protein kinase inhibitor 0 4.86906 1.4532e-05
methotrexate 500 uM 4.23561 8.9936e-05
methotrexate 125 uM 4.07797 0.00014059
methotrexate 250 uM 4.04666 0.00015357
drofenine hydrochloride 750 uM 4.0202 0.00010453
itraconazole 17.7 uM 3.7748 0.00022444
dihydromotuporamine C 15 uM 3.56502 0.00058376
thiabendazole 250 uM 3.28912 0.00095442
no drug minimal media 0 3.19843 0.012019

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for PEX21 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 0.78 uM 5.52976 0.015591
wiskostatin 29 uM 5.1312 5.8043e-06
nocodazole 10 ug/ml 4.95068 5.1656e-05
myriocin 0.2 ug/ml 4.91199 5.6181e-05
sorbitol 1.5e+06 uM 4.71687 3.5483e-05
mechlorethamine 62.5 uM 4.17152 0.026472
rapamycin 6 nM 3.96803 0.00017743
sorbitol 1.5e+06 uM 3.95696 0.00050893
methotrexate 250 uM 3.86259 0.00033417
licl 150 mM 3.83683 0.00025778

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YGR239C

Top 10 functional gene interactors with YGR239C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with PEX21 by heterozygous co-sensitivity:

Query Interactor Correlation
PEX21 PCK1 0.45332
PEX21 BIO5 0.43656
PEX21 FLO1 0.43346
PEX21 ECM29 0.41121
PEX21 YEL047C 0.40573
PEX21 SAY1 0.39515
PEX21 ICY2 0.39054
PEX21 FLO10 0.39049
PEX21 DAP2 0.38841
PEX21 PEX5 0.38362

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with PEX21 by homozygous co-sensitivity:

Query Interactor Correlation
PEX21 YOL150C 0.51072
PEX21 YGR053C 0.49283
PEX21 RPL41A 0.49014
PEX21 DOG1 0.47396
PEX21 VMR1 0.47014
PEX21 MGT1 0.46853
PEX21 RPL22B_p 0.44302
PEX21 YGR107W 0.43889
PEX21 YLR445W 0.4385
PEX21 HHO1 0.43846

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YGR239C

Other databases:

Visit YGR239C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


Download a plain text version of this page.