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Yeast Fitness
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YGR225W / AMA1



Section 1: Phenotypes.
Gene-drug relationships for YGR225W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGR225W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for AMA1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
ketoconazole 11.8 uM 15.4969 2.3411e-11
tunicamycin 0.15 uM 7.23036 1.0038e-06
miconazole 100 uM 4.79338 8.4278e-06
itraconazole 17.7 uM 4.15328 6.8528e-05
naringenin 1000 uM 3.45748 0.00058403
cantharidin 250 uM 3.34603 0.039447
20 degrees C 0 2.90953 0.0027572
5-fluorouracil 76.9 uM 2.5868 0.0064215
sanguinarine sulfate 250 uM 2.35574 0.011355
parthenolide 125 uM 2.3216 0.01232

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for AMA1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
23 degrees C 0 23.3363 2.3634e-10
5-fluorouracil 38.46 uM 13.7496 4.0228e-08
5-fluorouracil 19.2 uM 5.89773 7.5759e-05
synthetic complete for BY4743 0 5.2664 0.00018234
nystatin 10 uM 4.80956 0.00035666
nystatin 10 uM 4.39327 0.00067458
ph8 0 4.14071 0.0010048
sorbitol 1.5e+06 uM 3.8843 0.0015188
nacl 1000 uM 3.73692 0.001933
synthetic complete for BY4743 0 3.50118 0.0028576

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YGR225W

Top 10 functional gene interactors with YGR225W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with AMA1 by heterozygous co-sensitivity:

Query Interactor Correlation
AMA1 YGR226C 0.72292
AMA1 YPS5 0.6849
AMA1 STF2 0.68485
AMA1 MET14 0.65413
AMA1 SDH1 0.6404
AMA1 YFR056C 0.63338
AMA1 YKL131W 0.63158
AMA1 KNH1 0.61789
AMA1 YGR012W 0.61179
AMA1 MLC2 0.60972

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with AMA1 by homozygous co-sensitivity:

Query Interactor Correlation
AMA1 YDR107C 0.87393
AMA1 YDL121C 0.82319
AMA1 YCL006C_d 0.81721
AMA1 GDH3 0.81657
AMA1 YKL131W 0.81421
AMA1 LEU1 0.81252
AMA1 MGA1 0.78809
AMA1 YCL023C 0.78084
AMA1 YOR131C 0.77891
AMA1 MAL12 0.77059

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YGR225W

Other databases:

Visit YGR225W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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