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Yeast Fitness
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YGR200C / ELP2



Section 1: Phenotypes.
Gene-drug relationships for YGR200C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGR200C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ELP2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 3.91 uM 6.63019 8.8702e-08
acriflavinium hydrochloride 250 uM 5.08048 3.2024e-06
itraconazole 4.4 uM 4.47323 2.4333e-05
fenpropimorph 4.7 uM 4.35985 3.5227e-05
5-fluorocytosine 15.6 uM 4.15549 6.8046e-05
haloperidol 250 uM 4.01457 0.00010641
itraconazole 8.8 uM 3.67891 0.00030083
methotrexate 500 uM 3.33799 0.0010755
itraconazole 8.8 uM 3.33692 0.0008312
fluconazole 31.25 uM 3.27814 0.00098507

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for ELP2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 10.1794 3.3941e-09
latrunculin 0.78 uM 7.27388 0.0091904
rapamycin 9 nM 4.59063 0.022161
latrunculin 0.78 uM 3.63131 0.01798
latrunculin 0.78 uM 3.56373 0.0011096
latrunculin 0.78 uM 3.24276 0.041688
thimerosal 125 nM 2.08862 0.025609
latrunculin 3 uM 1.84421 0.040838
rapamycin 9 nM 1.76412 0.10988
bisphenol 125 uM 1.22259 0.11863

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YGR200C

Top 10 functional gene interactors with YGR200C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ELP2 by heterozygous co-sensitivity:

Query Interactor Correlation
ELP2 MTQ2 0.59214
ELP2 SWF1 0.57993
ELP2 THG1 0.53089
ELP2 ATP11 0.50414
ELP2 SED5 0.50149
ELP2 NPT1 0.50003
ELP2 RPG1 0.49651
ELP2 RRN5 0.49514
ELP2 SGD1 0.4912
ELP2 APC4 0.49052

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YGR200C

Other databases:

Visit YGR200C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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