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YGR188C / BUB1

Section 1: Phenotypes.
Gene-drug relationships for YGR188C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGR188C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for BUB1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 10.7064 2.0792e-12
dihydromotuporamine C 15 uM 5.66497 1.4346e-06
cantharidin 250 uM 5.21287 0.017443
clozapine 500 uM 5.20332 2.1083e-06
metergoline 250 uM 4.7446 9.919e-06
cantharidin 250 uM 4.21413 9.5602e-05
promazine hydrochloride 125 uM 4.16291 6.6452e-05
drofenine hydrochloride 750 uM 4.09622 8.2183e-05
fenpropimorph 4.7 uM 4.03237 0.0001006
methotrexate 500 uM 3.99379 0.0001782

More... (click to see all Heterozygous data)

Homozygous knockout:

Top 10 sensitivity-inducing conditions for BUB1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 2.74022 0.025947
synthetic complete for BY4743 0 1.2204 0.13836
synthetic complete for BY4743 0 1.11826 0.15714
synthetic complete for BY4743 0 0.969201 0.18848
synthetic complete for BY4743 0 0.0682783 0.47411

More... (click to see all Homozygous data)

Section 2: Co-fitness interactions.
Gene-gene relationships for YGR188C

Top 10 functional gene interactors with YGR188C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with BUB1 by heterozygous co-sensitivity:

Query Interactor Correlation
BUB1 RPS27B 0.69354
BUB1 RPS20 0.67918
BUB1 RPS16B 0.67746
BUB1 RPS17A 0.67546
BUB1 RPS24A 0.66087
BUB1 RPS6A 0.66033
BUB1 RPS3 0.65657
BUB1 RPS23B 0.65484
BUB1 RPS13 0.65209
BUB1 RPS21B 0.65036

More... (click to see all interactions)

Enriched GO terms of interactors

Homozygous co-fitness interactions

[No homozygous results.]

External information about YGR188C

Other databases:

Visit YGR188C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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