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YGR181W / TIM13



Section 1: Phenotypes.
Gene-drug relationships for YGR181W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGR181W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for TIM13 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
ketoconazole 11.8 uM 9.34714 3.4842e-08
dyclonine 500 uM 5.02901 0.00014733
latrunculin 6.25 uM 4.97492 6.8831e-05
itraconazole 8.8 uM 4.93736 5.1968e-06
amphotericin b 0.31 uM 4.93277 5.2777e-06
fenpropimorph 4.7 uM 4.5935 1.6381e-05
alverine citrate 500 uM 4.56247 0.022417
miconazole 100 uM 4.1302 7.3762e-05
itraconazole 8.8 uM 4.0888 8.4141e-05
tryptanthrin 250 uM 4.03264 0.00015975

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for TIM13 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mms 0.002 % 39.7884 0.00031553
chemdiv 275 62 uM 15.5839 < 1e-12
cocl2 1250 uM 12.538 < 1e-12
mms 0.002 % 12.0719 < 1e-12
tryptanthrin 250 uM 10.4881 < 1e-12
sorbitol 1.5e+06 uM 10.234 6.534e-11
sorbitol 1.5e+06 uM 10.2272 6.4665e-07
psoralen 62.5 uM 9.4057 2.7345e-11
zncl2 1875 uM 9.17344 5.0647e-11
bisphenol s 100 uM 7.68173 1.8773e-08

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YGR181W

Top 10 functional gene interactors with YGR181W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with TIM13 by heterozygous co-sensitivity:

Query Interactor Correlation
TIM13 TMS1 0.43572
TIM13 YLR126C 0.43324
TIM13 RTA1 0.42009
TIM13 VPS62 0.41519
TIM13 YGR146C 0.40443
TIM13 RTS3 0.40287
TIM13 YPR071W 0.39933
TIM13 DPB4 0.39731
TIM13 YJR149W 0.39576
TIM13 QCR9 0.39199

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with TIM13 by homozygous co-sensitivity:

Query Interactor Correlation
TIM13 YGR182C 0.79649
TIM13 MGA2 0.49327
TIM13 URA1 0.41942
TIM13 IZH2 0.36715
TIM13 UBP1 0.36357
TIM13 YKL098W 0.36271
TIM13 YMR057C 0.35696
TIM13 DLT1 0.34486
TIM13 LEU3 0.34085
TIM13 URA4 0.33585

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YGR181W

Other databases:

Visit YGR181W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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