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Yeast Fitness

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YGR158C / MTR3

Section 1: Phenotypes.
Gene-drug relationships for YGR158C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGR158C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for MTR3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
5-fluorouracil 76.8 uM 5.71333 1.2465e-06
amphotericin b 0.62 uM 4.87178 6.48e-06
5-fluorocytosine 15.6 uM 4.62563 1.473e-05
5-fluorocytosine 15.6 uM 4.61716 1.5148e-05
methotrexate 250 uM 4.23394 9.0364e-05
5-fluorouracil 19.2 uM 4.23286 5.3104e-05
fenpropimorph 1.2 uM 3.71825 0.00026687
fluconazole 31.25 uM 3.64993 0.00032847
amphotericin b 0.62 uM 3.5055 0.00050658
methotrexate 125 uM 3.40038 0.00091049

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YGR158C

Top 10 functional gene interactors with YGR158C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with MTR3 by heterozygous co-sensitivity:

Query Interactor Correlation
MTR3 RRP46 0.59481
MTR3 RLP7 0.50462
MTR3 DIS3 0.49158
MTR3 RRP42 0.46439
MTR3 NOP1 0.44455
MTR3 RPS29B 0.42919
MTR3 NOP2 0.42624
MTR3 RRP4 0.42083
MTR3 RPS0B 0.41526
MTR3 RPS0A 0.41418

More... (click to see all interactions)

Enriched GO terms of interactors

Homozygous co-fitness interactions

[No homozygous results.]

External information about YGR158C

Other databases:

Visit YGR158C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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