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Yeast Fitness
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YGR135W / PRE9



Section 1: Phenotypes.
Gene-drug relationships for YGR135W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGR135W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for PRE9 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 14.2484 < 1e-12
dyclonine 500 uM 7.04178 6.7649e-06
dyclonine 500 uM 6.07371 2.777e-05
fenpropimorph 4.7 uM 5.51213 7.308e-07
dihydromotuporamine C 15 uM 5.24051 4.9352e-06
no drug minimal media 0 4.9229 0.0021932
paraquat 5000 uM 4.63389 2.8704e-05
dihydromotuporamine C 15 uM 4.535 3.817e-05
haloperidol 250 uM 4.42188 0.00041642
dihydromotuporamine C 15 uM 3.99659 0.0001768

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for PRE9 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
phosphatase inhibitor 3 uM 11.086 < 1e-12
mitomycin c 1000 uM 10.9337 < 1e-12
mncl2 2 mM 9.39893 2.7838e-11
synthetic complete for BY4743 0 9.28362 0.0057024
synthetic complete for BY4743 0 7.73484 0.0081535
synthetic complete for BY4743 0 6.26431 0.012274
mms 0.002 % 6.19347 0.012546
sodium fluoride 20000 uM 5.8231 7.3085e-07
camptothecin 30 ug/ml 5.50299 1.9067e-06
k2cr2o7 125 uM 5.19018 4.8657e-06

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YGR135W

Top 10 functional gene interactors with YGR135W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with PRE9 by heterozygous co-sensitivity:

Query Interactor Correlation
PRE9 PRE2 0.58537
PRE9 UMP1 0.55925
PRE9 PUP2 0.54749
PRE9 SCL1 0.51201
PRE9 PUP1 0.48939
PRE9 PRE3 0.47493
PRE9 PRE6 0.45815
PRE9 PRE10 0.44725
PRE9 PUP3 0.42955
PRE9 PRE7 0.41851

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
 
Homozygous co-fitness interactions

Top 10 interactors with PRE9 by homozygous co-sensitivity:

Query Interactor Correlation
PRE9 IRC25 0.63853
PRE9 YPL144W 0.61395
PRE9 YNL213C 0.52415
PRE9 RPN10 0.49659
PRE9 ATG11 0.49411
PRE9 MUB1 0.47459
PRE9 UBR2 0.47148
PRE9 EUG1 0.41786
PRE9 YLR199C 0.40981
PRE9 MIP1 0.4052

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YGR135W

Other databases:

Visit YGR135W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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