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YGR118W / RPS23A



Section 1: Phenotypes.
Gene-drug relationships for YGR118W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGR118W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPS23A Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 6.8597 4.6215e-08
drofenine hydrochloride 750 uM 6.06513 1.0725e-07
clozapine 500 uM 4.31618 4.0586e-05
dmso 4% 4 uM 3.39184 0.00070828
splitomicin 250 uM 2.85083 0.0037858
dihydromotuporamine C 15 uM 2.47168 0.0094777
dihydromotuporamine C 15 uM 2.39932 0.011211
mechlorethamine 62.5 uM 2.36262 0.011169
fenpropimorph 4.7 uM 2.21968 0.015651
trifluoperazine dihydrochloride 31.25 uM 2.06503 0.02355

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RPS23A Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 14.0818 1.8457e-11
rapamycin 9 nM 4.44209 0.010608
rapamycin 9 nM 4.15626 0.026651
norcantharidin 2500 uM 4.01997 0.0001529
minimal media 0 3.74021 0.00081459
chemdiv 218 250 uM 3.70931 0.00036928
chlorambucil 250 uM 2.77791 0.0044204
rapamycin 9 nM 2.48925 0.065262
benzaldehyde 0.003 % 1.99722 0.030574
sorbitol 1.5e+06 uM 1.9322 0.035088

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YGR118W

Top 10 functional gene interactors with YGR118W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RPS23A by heterozygous co-sensitivity:

Query Interactor Correlation
RPS23A RPS23B 0.69181
RPS23A RPS6A 0.64711
RPS23A YPR136C 0.63302
RPS23A RRP9 0.62731
RPS23A RPS3 0.6268
RPS23A BUB1 0.61651
RPS23A PNO1 0.60151
RPS23A RPS27B 0.60116
RPS23A RPS17A 0.57763
RPS23A UTP6 0.57437

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
 
Homozygous co-fitness interactions

Top 10 interactors with RPS23A by homozygous co-sensitivity:

Query Interactor Correlation
RPS23A RPS11B 0.82008
RPS23A SLX9 0.70806
RPS23A RPL11B 0.6875
RPS23A SSF1 0.68005
RPS23A FYV12 0.62618
RPS23A RPS6B 0.6171
RPS23A RPL4A 0.61445
RPS23A RPL34A 0.58715
RPS23A RPL24B 0.58647
RPS23A RPS29B 0.58066

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YGR118W

Other databases:

Visit YGR118W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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