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Yeast Fitness
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YGR085C / RPL11B



Section 1: Phenotypes.
Gene-drug relationships for YGR085C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGR085C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPL11B Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
5-fluorouracil 38.5 uM 3.38224 0.0019
lovastatin 62.5 uM 2.94886 0.0024781
no drug minimal media 0 2.8865 0.017163
nitromide 1000 uM 2.75892 0.0041191
cantharidin 250 uM 2.70456 0.056919
methotrexate 125 uM 2.41386 0.0098667
methotrexate 125 uM 2.37786 0.010766
floxuridine 3.37 uM 2.36798 0.015409
cantharidin 250 uM 2.36579 0.070833
caspofungin 50 nM 2.31713 0.012451

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RPL11B Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
rapamycin 9 nM 10.1753 0.0047604
rapamycin 9 nM 10.0787 0.00104
potassium disulfite 2500 uM 9.86254 5.5232e-09
rapamycin 9 nM 2.81393 0.053248
cuso4 10000 uM 2.65058 0.0060551
norcantharidin 2500 uM 2.55655 0.007604
chemdiv 246 62 uM 2.30894 0.013577
streptovitacin 31.25 uM 2.26118 0.01513
chemdiv 218 250 uM 2.1948 0.017553
benzaldehyde 0.003 % 2.01069 0.029791

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YGR085C

Top 10 functional gene interactors with YGR085C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RPL11B by heterozygous co-sensitivity:

Query Interactor Correlation
RPL11B YGR015C 0.52994
RPL11B ARC1 0.52215
RPL11B YER139C 0.50415
RPL11B NMD4 0.49046
RPL11B CWC27 0.48049
RPL11B PDH1 0.47116
RPL11B MRPL7 0.47059
RPL11B ROG1 0.47042
RPL11B MMS2 0.46064
RPL11B MND2 0.4581

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with RPL11B by homozygous co-sensitivity:

Query Interactor Correlation
RPL11B SSF1 0.75508
RPL11B RPS23A 0.6875
RPL11B RPL34A 0.66338
RPL11B RPS11B 0.64919
RPL11B YDL063C 0.6119
RPL11B SLX9 0.60918
RPL11B RPL24B 0.6047
RPL11B RPL4A 0.6021
RPL11B RPL9B 0.59166
RPL11B RPL17B 0.58876

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YGR085C

Other databases:

Visit YGR085C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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