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Yeast Fitness

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YGR060W / ERG25

Section 1: Phenotypes.
Gene-drug relationships for YGR060W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGR060W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ERG25 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cocl2 1250 uM 5.31509 3.9719e-06
wiskostatin 29 uM 4.68893 2.4485e-05
telomerase inhibitor ix (Biomol) 500 uM 4.29913 7.5047e-05
methotrexate 500 uM 4.2687 8.1849e-05
ketoconazole 11.8 uM 3.64967 0.0010801
bufexamac 1000 uM 3.08509 0.0017023
5-fluorouracil 38.5 uM 2.75512 0.0070424
bufexamac 1000 uM 2.64327 0.0055609
tryptanthrin 250 uM 2.38133 0.011684
psoralen 62.5 uM 2.20455 0.017397

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YGR060W

Top 10 functional gene interactors with YGR060W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with ERG25 by heterozygous co-sensitivity:

Query Interactor Correlation
ERG25 TPC1 0.66032
ERG25 ATG1 0.62585
ERG25 MRP8 0.59447
ERG25 YMR041C 0.57482
ERG25 YLR202C 0.57024
ERG25 PET9 0.56962
ERG25 MOT1 0.56537
ERG25 JAC1 0.56063
ERG25 PXA2 0.56004
ERG25 SWC7 0.55958

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YGR060W

Other databases:

Visit YGR060W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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