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YGR040W / KSS1



Section 1: Phenotypes.
Gene-drug relationships for YGR040W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGR040W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for KSS1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
ketoconazole 11.8 uM 9.15015 4.6564e-08
no drug minimal media 0 5.96784 0.00094553
latrunculin 3.91 uM 5.57326 1.8732e-06
no drug minimal media 0 5.53228 0.0013231
no drug minimal media 0 5.07585 0.001924
lapachol 500 uM 4.55268 1.8743e-05
drofenine hydrochloride 750 uM 4.4269 2.8316e-05
bufexamac 1000 uM 4.00879 0.00010836
itraconazole 8.8 uM 3.90467 0.00015016
thiabendazole 500 uM 3.69729 0.00028448

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for KSS1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cadmium chloride 7.81 uM 5.92976 5.312e-07
synthetic complete for BY4743 0 5.61521 0.00011147
synthetic complete for BY4743 0 5.59981 0.00011387
nystatin 10 uM 5.1631 0.00021166
methotrexate 250 uM 4.8885 2.2551e-05
nystatin 10 uM 4.31421 0.00076347
tryptophan dropout 0 4.06641 0.0011316
synthetic complete for BY4743 0 4.0346 0.0011909
nacl 1000 uM 3.53733 0.0026903
ph8 0 3.43687 0.0031824

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YGR040W

Top 10 functional gene interactors with YGR040W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with KSS1 by heterozygous co-sensitivity:

Query Interactor Correlation
KSS1 MIC17 0.49769
KSS1 CAM1 0.49665
KSS1 YAL066W 0.49466
KSS1 COS10 0.47596
KSS1 YGR051C 0.46494
KSS1 YGR266W 0.45785
KSS1 REH1 0.4519
KSS1 VBA1 0.4478
KSS1 UBP11 0.43315
KSS1 YPL216W 0.43119

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with KSS1 by homozygous co-sensitivity:

Query Interactor Correlation
KSS1 FMP48 0.54651
KSS1 ASG7 0.54096
KSS1 ECM8 0.5366
KSS1 BAG7 0.53593
KSS1 HEF3 0.53584
KSS1 YFL042C 0.51861
KSS1 TEC1 0.50655
KSS1 TCB2 0.50594
KSS1 YBR090C 0.49869
KSS1 YOR227W 0.49273

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YGR040W

Other databases:

Visit YGR040W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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