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Yeast Fitness
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YGL254W / FZF1



Section 1: Phenotypes.
Gene-drug relationships for YGL254W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGL254W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for FZF1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 250 uM 3.93474 0.00013671
methotrexate 250 uM 3.53885 0.00045868
nimustine 1000 uM 3.52715 0.00047497
lovastatin 154.5 uM 3.1965 0.001244
mechlorethamine 62.5 uM 2.6251 0.0058255
nocodazole 6.9 uM 2.48331 0.027807
thiabendazole 500 uM 2.45898 0.0088355
benomyl 13.8 uM 2.41505 0.030243
alverine citrate 500 uM 2.4115 0.0099236
caspofungin 10 nM 2.24525 0.014748

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for FZF1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
23 degrees C 0 6.00871 6.5292e-05
l-dopa 12.5 ug/ml 4.86756 1.2745e-05
synthetic complete for BY4743 0 4.4983 0.010256
nitric oxide 800 uM 4.39118 8.3796e-05
synthetic complete for BY4743 0 3.90377 0.0014715
synthetic complete for BY4743 0 3.42951 0.013274
mitomycin c 1000 uM 3.03585 0.0022896
nystatin 10 uM 2.96189 0.007121
curcumin 150 uM 2.63199 0.00846
synthetic complete for BY4743 0 2.62366 0.012719

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YGL254W

Top 10 functional gene interactors with YGL254W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with FZF1 by heterozygous co-sensitivity:

Query Interactor Correlation
FZF1 RPL22B 0.72519
FZF1 ADH7 0.70145
FZF1 YER121W 0.69376
FZF1 GTS1 0.67837
FZF1 SAK1 0.66592
FZF1 ARR2 0.65349
FZF1 ZIP2 0.64202
FZF1 RCK1 0.64159
FZF1 MSH3 0.63813
FZF1 YGR021W 0.63762

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with FZF1 by homozygous co-sensitivity:

Query Interactor Correlation
FZF1 YFL042C 0.59224
FZF1 XPT1 0.5684
FZF1 PKP1 0.53852
FZF1 PXA2 0.5366
FZF1 YMR141C 0.53649
FZF1 YFR057W 0.53568
FZF1 YGR045C 0.52956
FZF1 UBX7 0.52846
FZF1 YPR126C 0.52846
FZF1 SAM3 0.52803

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YGL254W

Other databases:

Visit YGL254W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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