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Yeast Fitness

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YGL245W / GUS1

Section 1: Phenotypes.
Gene-drug relationships for YGL245W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGL245W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for GUS1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
dna protein kinase inhibitor 0 10.2766 5.7896e-12
ketoconazole 11.8 uM 9.55958 2.5607e-08
dihydromotuporamine C 15 uM 6.03383 4.9212e-07
dihydromotuporamine C 15 uM 4.71025 2.3021e-05
5-fluorouracil 38.5 uM 3.62773 0.0011314
5-fluorouracil 19.2 uM 3.31564 0.0011413
methotrexate 500 uM 3.19447 0.0015708
no drug minimal media 0 3.16901 0.0096715
5-fluorouracil 76.8 uM 3.03708 0.0023622
dyclonine 500 uM 2.89111 0.0028977

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YGL245W

Top 10 functional gene interactors with YGL245W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with GUS1 by heterozygous co-sensitivity:

Query Interactor Correlation
GUS1 PBN1 0.53164
GUS1 RAI1 0.52982
GUS1 TFC4 0.51184
GUS1 SNU71 0.50752
GUS1 POP8 0.50719
GUS1 NCS6 0.50543
GUS1 REF2 0.49321
GUS1 YGR073C 0.49094
GUS1 TUF1 0.48798
GUS1 MCM6 0.48747

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YGL245W

Other databases:

Visit YGL245W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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