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Yeast Fitness
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YGL213C / SKI8



Section 1: Phenotypes.
Gene-drug relationships for YGL213C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGL213C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SKI8 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
dihydromotuporamine C 15 uM 4.16561 0.00010972
dna protein kinase inhibitor 0 3.86197 0.00025766
dihydromotuporamine C 15 uM 3.35601 0.0010251
dmso 4% 4 uM 2.94515 0.0025032
fecl4 2500 uM 2.93964 0.0030281
latrunculin 6.25 uM 2.83864 0.0059282
allyl sulfide 0.12 % 2.78327 0.0044779
potassium disulfite 2500 uM 2.71782 0.0052596
mechlorethamine 62.5 uM 2.52828 0.0074403
caspofungin 10 nM 2.29794 0.013031

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for SKI8 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 9.16818 1.6702e-08
l-dopa 12.5 ug/ml 5.46479 2.1379e-06
hygromycin 13.75 uM 5.16738 5.2092e-06
tryptophan dropout 0 5.0848 0.00023722
methotrexate 250 uM 5.07417 1.3817e-05
phosphatase inhibitor 3 uM 4.96524 9.5274e-06
synthetic complete for BY4743 0 4.91126 0.00030638
paraquat 5000 uM 4.81985 1.4688e-05
methotrexate 250 uM 4.66785 4.0387e-05
chemdiv 232 62 uM 4.36759 5.5801e-05

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YGL213C

Top 10 functional gene interactors with YGL213C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SKI8 by heterozygous co-sensitivity:

Query Interactor Correlation
SKI8 HNM1 0.49596
SKI8 EBS1 0.47162
SKI8 NSA1 0.46978
SKI8 RMD8 0.4661
SKI8 CLG1 0.46015
SKI8 YDR535C 0.45636
SKI8 HSP42 0.45002
SKI8 YPR130C 0.43779
SKI8 URA1 0.43772
SKI8 YGR021W 0.42952

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with SKI8 by homozygous co-sensitivity:

Query Interactor Correlation
SKI8 SKI2 0.71169
SKI8 YGL214W 0.68416
SKI8 SKI3 0.68149
SKI8 DBR1 0.63319
SKI8 NCS6 0.59129
SKI8 UBA4 0.5786
SKI8 RPL31B 0.54227
SKI8 KTI12 0.53654
SKI8 GPR1 0.51621
SKI8 ELP3 0.51535

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
  • None




External information about YGL213C

Other databases:

Visit YGL213C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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