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Yeast Fitness
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YGL208W / SIP2



Section 1: Phenotypes.
Gene-drug relationships for YGL208W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGL208W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SIP2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 250 uM 7.10383 2.3224e-08
paraquat 2000 uM 5.8327 8.8134e-07
methotrexate 125 uM 5.48709 2.4071e-06
5-fluorouracil 19.2 uM 5.39259 3.1694e-06
methotrexate 125 uM 5.2375 4.9787e-06
5-fluorouracil 125 uM 5.15557 2.4809e-06
methotrexate 125 uM 4.72207 2.2247e-05
methotrexate 500 uM 4.70725 2.3221e-05
dna protein kinase inhibitor 0 4.33029 6.866e-05
dihydromotuporamine C 15 uM 4.25961 8.3998e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for SIP2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 400 uM 4.33923 0.00073407
carboplatin 250 uM 4.24793 7.9116e-05
synthetic complete for BY4743 0 4.05053 0.013551
rapamycin 5 nM 3.98141 0.00017077
zncl2 1875 uM 3.34779 0.0010004
5-fluorouracil 19.2 uM 3.31292 0.0039203
5-fluorouracil 19.1 uM 3.2912 0.0014355
synthetic complete for BY4743 0 3.23812 0.015865
5-fluorouracil 38.5 uM 3.1207 0.0031111
sorbitol 1.5e+06 uM 3.0197 0.0038616

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YGL208W

Top 10 functional gene interactors with YGL208W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SIP2 by heterozygous co-sensitivity:

Query Interactor Correlation
SIP2 HSP30 0.62916
SIP2 YPR115W 0.60537
SIP2 YCR099C 0.57542
SIP2 CAP1 0.5708
SIP2 YCR023C 0.55474
SIP2 IVY1 0.55449
SIP2 UGA1 0.5468
SIP2 ALG3 0.54498
SIP2 KIP3 0.53604
SIP2 MOH1 0.53406

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with SIP2 by homozygous co-sensitivity:

Query Interactor Correlation
SIP2 BDH1 0.69495
SIP2 CWP1 0.66974
SIP2 YNL303W 0.65528
SIP2 ODC2 0.65239
SIP2 YGL082W 0.64466
SIP2 YTA6 0.64224
SIP2 IAH1 0.62788
SIP2 YGL039W 0.62673
SIP2 FRT2 0.60976
SIP2 YCR102C 0.60787

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YGL208W

Other databases:

Visit YGL208W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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