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Yeast Fitness

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YGL201C / MCM6

Section 1: Phenotypes.
Gene-drug relationships for YGL201C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGL201C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for MCM6 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
dna protein kinase inhibitor 0 9.44063 4.5468e-11
dihydromotuporamine C 15 uM 6.76606 6.0264e-08
5-fluorouracil 38.5 uM 6.03719 8.6333e-06
dihydromotuporamine C 15 uM 5.16537 6.1418e-06
methotrexate 250 uM 4.98864 1.0269e-05
aureobasidin a 0.02 ug/ml 4.69486 2.4069e-05
methotrexate 500 uM 3.667 0.00044177
floxuridine 3.37 uM 3.59809 0.0012045
latrunculin 6.25 uM 3.55721 0.0013131
sulfanilamide 62.5 uM 3.47719 0.00055096

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YGL201C

Top 10 functional gene interactors with YGL201C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with MCM6 by heterozygous co-sensitivity:

Query Interactor Correlation
MCM6 YGL102C 0.62771
MCM6 CDC37 0.62733
MCM6 BUD13 0.60228
MCM6 YGL069C 0.59952
MCM6 SEC15 0.55645
MCM6 SEC7 0.54985
MCM6 YBL073W 0.53959
MCM6 UBP3 0.53499
MCM6 YJU2 0.52568
MCM6 PET122 0.52507

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YGL201C

Other databases:

Visit YGL201C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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