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Yeast Fitness
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YGL175C / SAE2



Section 1: Phenotypes.
Gene-drug relationships for YGL175C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGL175C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SAE2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
thiabendazole 500 uM 4.78384 8.7009e-06
dmso 4% 4 uM 4.35515 3.5768e-05
fk506 0.1 ug/ml 3.70971 0.00039283
fk506 0.1 ug/ml 3.59618 0.00053624
lovastatin 154.5 uM 3.21183 0.001191
amphotericin b 0.31 uM 3.05626 0.0018445
methotrexate 125 uM 2.82828 0.0034288
thiabendazole 500 uM 2.57117 0.0066804
helenine 250 uM 2.37323 0.010887
tryptanthrin 250 uM 2.36533 0.012121

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for SAE2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mechlorethamine 62.5 uM 15.7119 0.0020132
rapamycin 9 nM 13.1753 0.0028557
cisplatin 500 uM 11.0768 1.2093e-11
cisplatin 66 uM 10.9315 1.6076e-11
acriflavinium hydrochloride 250 uM 9.66471 2.146e-10
mechlorethamine 62.5 uM 9.65172 0.0052824
amsacrine 500 uM 9.33201 3.3226e-11
cisplatin 500 uM 9.11761 6.9976e-10
cisplatin 66 uM 9.0439 8.23e-10
calyculin a 2.5 uM 8.45316 3.5798e-10

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YGL175C

Top 10 functional gene interactors with YGL175C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SAE2 by heterozygous co-sensitivity:

Query Interactor Correlation
SAE2 BUR6 0.58758
SAE2 DUO1 0.56973
SAE2 PGS1 0.56666
SAE2 BUD26 0.55399
SAE2 CCA1 0.55338
SAE2 CEG1 0.55284
SAE2 SMP3 0.5469
SAE2 CDC43 0.54562
SAE2 STU1 0.54351
SAE2 POP8 0.54181

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with SAE2 by homozygous co-sensitivity:

Query Interactor Correlation
SAE2 RAD59 0.76857
SAE2 PSY2 0.71105
SAE2 MMS4 0.67945
SAE2 MUS81 0.67278
SAE2 YBR099C 0.64248
SAE2 PPH3 0.63604
SAE2 SLX4 0.62177
SAE2 REV3 0.58149
SAE2 SHU2 0.55049
SAE2 CSM2 0.5476

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YGL175C

Other databases:

Visit YGL175C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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