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YGL172W / NUP49

Section 1: Phenotypes.
Gene-drug relationships for YGL172W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGL172W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for NUP49 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
atorvastatin 62.5 uM 3.62337 0.00035592
dmso 4% 4 uM 3.27376 0.00099756
mechlorethamine 62.5 uM 2.709 0.004693
cantharidin disodium 100 uM 2.61495 0.0067487
amphotericin b 0.31 uM 2.33467 0.011942
miconazole 50 nM 2.30929 0.017304
haloperidol 250 uM 2.18852 0.024569
caspofungin 50 nM 1.95937 0.028008
amitriptyline hydrochloride 250 uM 1.93215 0.029691
itraconazole 17.7 uM 1.87651 0.033401

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YGL172W

Top 10 functional gene interactors with YGL172W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with NUP49 by heterozygous co-sensitivity:

Query Interactor Correlation
NUP49 HES1 0.58972
NUP49 CLP1 0.57335
NUP49 APC5 0.54125
NUP49 NSA1 0.50852
NUP49 GET1 0.50162
NUP49 TSA2 0.49713
NUP49 UTP11 0.49576
NUP49 YRB30 0.49436
NUP49 RPN14 0.484
NUP49 SUA5 0.48126

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YGL172W

Other databases:

Visit YGL172W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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