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YGL171W / ROK1

Section 1: Phenotypes.
Gene-drug relationships for YGL171W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGL171W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ROK1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
nitromide 1000 uM 5.02655 3.8448e-06
methotrexate 125 uM 4.09652 0.00013342
mechlorethamine 62.5 uM 4.02324 0.00010354
emodin 1000 uM 3.87147 0.0001665
latrunculin 6.25 uM 3.56457 0.0012928
dyclonine 500 uM 3.43187 0.00062979
quinacrine hydrochloride 1000 uM 2.90912 0.0027603
chemdiv 41 500 uM 2.85925 0.003707
nocodazole 6.9 uM 2.85373 0.017834
alverine citrate 500 uM 2.61361 0.0059988

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YGL171W

Top 10 functional gene interactors with YGL171W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with ROK1 by heterozygous co-sensitivity:

Query Interactor Correlation
ROK1 CDC1 0.66348
ROK1 CBS2 0.6029
ROK1 CEG1 0.58711
ROK1 POP8 0.58484
ROK1 DUO1 0.57783
ROK1 PRP42 0.57616
ROK1 SUP35 0.5614
ROK1 FMN1 0.55971
ROK1 ERD2 0.55515
ROK1 MRPL38 0.54476

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YGL171W

Other databases:

Visit YGL171W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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