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YGL167C / PMR1

Section 1: Phenotypes.
Gene-drug relationships for YGL167C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGL167C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for PMR1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
caspofungin 10 nM 15.2068 < 1e-12
caspofungin 10 nM 14.8417 < 1e-12
caspofungin 10 nM 14.5153 < 1e-12
caspofungin 10 nM 14.504 < 1e-12
clotrimazole 1 uM 6.60492 1.6264e-08
fenpropimorph 4.7 uM 6.27852 5.092e-08
mitomycin c 1000 uM 5.51146 7.3251e-07
thiabendazole 250 uM 5.03419 3.7466e-06
itraconazole 17.7 uM 4.74263 9.9846e-06
amphotericin b 10 uM 3.97968 0.00011875

More... (click to see all Heterozygous data)

Homozygous knockout:

Top 10 sensitivity-inducing conditions for PMR1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 0.78 uM 9.9689 0.001074
synthetic complete for BY4743 0 8.90172 2.2906e-05
synthetic complete for BY4743 0 8.40302 3.3255e-05
rapamycin 9 nM 7.84036 0.0021606
rapamycin 9 nM 6.91616 0.010136
latrunculin 0.78 uM 6.12381 0.012822
synthetic complete for BY4743 0 6.06121 0.00025513
papuamide b 0.7 ug/ml 4.58552 0.00011472
synthetic complete for BY4743 0 4.43042 0.0034127
potassium disulfite 2500 uM 4.42108 0.00016487

More... (click to see all Homozygous data)

Section 2: Co-fitness interactions.
Gene-gene relationships for YGL167C

Top 10 functional gene interactors with YGL167C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with PMR1 by heterozygous co-sensitivity:

Query Interactor Correlation
PMR1 HUR1 0.77572
PMR1 VMA7 0.60822
PMR1 YNL181W 0.57812
PMR1 VMA10 0.53914
PMR1 VMA4 0.52042
PMR1 MSD1 0.49934
PMR1 PKC1 0.49284
PMR1 HES1 0.4927
PMR1 APC5 0.48855
PMR1 RPB2 0.47263

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YGL167C

Other databases:

Visit YGL167C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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