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Yeast Fitness
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YGL121C / GPG1



Section 1: Phenotypes.
Gene-drug relationships for YGL121C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGL121C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for GPG1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
ketoconazole 11.8 uM 13.5317 1.7718e-10
cantharidin 250 uM 7.74644 0.0081297
cantharidin 250 uM 6.75966 0.010596
cantharidin 250 uM 6.74045 0.010655
cantharidin 250 uM 6.1621 0.012669
nocodazole 2 ug/ml 6.05555 1.1089e-07
cantharidin 250 uM 6.05207 0.013116
cantharidin 250 uM 5.01215 0.018788
methotrexate 500 uM 4.97979 1.0537e-05
methotrexate 500 uM 4.82306 1.6606e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for GPG1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
23 degrees C 0 11.9426 1.528e-07
mechlorethamine 62.5 uM 4.50167 0.022985
mechlorethamine 62.5 uM 4.48141 0.01036
cadmium chloride 7.81 uM 4.33092 6.2115e-05
hydroxyurea 100000 uM 4.24772 7.9164e-05
synthetic complete for BY4743 0 4.05692 0.001149
mechlorethamine 62.5 uM 3.73852 0.032342
synthetic complete for BY4743 0 3.49394 0.0028924
ph8 0 3.40099 0.0010897
sorbitol 1.5e+06 uM 2.94207 0.0045559

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YGL121C

Top 10 functional gene interactors with YGL121C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with GPG1 by heterozygous co-sensitivity:

Query Interactor Correlation
GPG1 MPD1 0.51294
GPG1 AAC1 0.422
GPG1 URN1 0.40201
GPG1 APA1 0.37752
GPG1 PNC1 0.37378
GPG1 YFR035C 0.3717
GPG1 SSB1 0.37094
GPG1 NCA2 0.36335
GPG1 APL1 0.35377
GPG1 COX5B 0.35229

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with GPG1 by homozygous co-sensitivity:

Query Interactor Correlation
GPG1 YAL066W 0.54649
GPG1 CIT2 0.52905
GPG1 YBR271W 0.50085
GPG1 YOR283W 0.49968
GPG1 FOB1 0.48128
GPG1 YGR011W 0.46176
GPG1 SNG1 0.46032
GPG1 YOR227W 0.45889
GPG1 KIP1 0.45028
GPG1 YPR053C 0.44972

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YGL121C

Other databases:

Visit YGL121C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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