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YGL114W / YGL114W



Section 1: Phenotypes.
Gene-drug relationships for YGL114W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGL114W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YGL114W Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
ketoconazole 11.8 uM 11.5976 1.6836e-09
nocodazole 2 ug/ml 6.29786 4.7592e-08
methotrexate 125 uM 4.04537 9.655e-05
5-fluorouracil 125 uM 3.09431 0.001659
tunicamycin 0.15 uM 2.79861 0.0064392
atorvastatin 125 uM 2.55477 0.0069621
alverine citrate 500 uM 2.52752 0.01327
miconazole 50 nM 2.29879 0.020143
ursodiol 1000 uM 2.27165 0.013864
naringenin 1000 uM 2.2279 0.015356

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YGL114W Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
23 degrees C 0 14.2007 2.9553e-08
mitomycin c 1000 uM 6.44555 1.143e-07
mechlorethamine 62.5 uM 5.01249 0.018786
licl 100 mM 4.19058 0.0002748
allyl disulfide 0.06 % 3.97044 0.00017621
hydroxyurea 50000 uM 3.92983 0.00019789
ph8 0 3.38924 0.0011224
phosphatase inhibitor 2 uM 3.36138 0.00096425
mechlorethamine 62.5 uM 2.94147 0.0043633
methotrexate 250 uM 2.90333 0.0037162

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YGL114W

Top 10 functional gene interactors with YGL114W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with YGL114W by heterozygous co-sensitivity:

Query Interactor Correlation
YGL114W FAU1 0.60793
YGL114W CUE3 0.59213
YGL114W STF2 0.5849
YGL114W YGL262W 0.58421
YGL114W TAD1 0.56864
YGL114W MET16 0.56596
YGL114W YDR539W 0.56418
YGL114W ADH4 0.56415
YGL114W HXK2 0.55697
YGL114W COS12 0.55092

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
 
Homozygous co-fitness interactions

Top 10 interactors with YGL114W by homozygous co-sensitivity:

Query Interactor Correlation
YGL114W OAF1 0.54329
YGL114W YHI9 0.51492
YGL114W PAU7 0.49823
YGL114W YET2 0.49539
YGL114W SCM4 0.49434
YGL114W YKL222C 0.49049
YGL114W YCR007C 0.48977
YGL114W YGR093W 0.48242
YGL114W DUG1 0.48146
YGL114W YDL114W 0.48035

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YGL114W

Other databases:

Visit YGL114W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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