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Yeast Fitness

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YGL113W / SLD3

Section 1: Phenotypes.
Gene-drug relationships for YGL113W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGL113W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SLD3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
ketoconazole 11.8 uM 11.9187 1.1352e-09
dyclonine 500 uM 4.09379 8.2819e-05
nocodazole 2 ug/ml 3.97263 0.00012141
tryptanthrin 250 uM 3.89615 0.00023424
atorvastatin 62.5 uM 3.14833 0.0014257
quinacrine hydrochloride 1000 uM 2.77101 0.0039902
fluconazole 130.6 uM 2.74382 0.0042854
methotrexate 250 uM 2.70877 0.0053771
5-fluorocytosine 15.6 uM 2.68616 0.0049793
hydroxyurea 100000 uM 2.61735 0.0059419

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YGL113W

Top 10 functional gene interactors with YGL113W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with SLD3 by heterozygous co-sensitivity:

Query Interactor Correlation
SLD3 LTV1 0.82662
SLD3 IPI3 0.82479
SLD3 YDR196C 0.80715
SLD3 URB1 0.80531
SLD3 SPC19 0.79666
SLD3 RAD3 0.79383
SLD3 MMS1 0.79005
SLD3 YGR251W 0.7876
SLD3 SDS22 0.78284
SLD3 SEC9 0.78276

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YGL113W

Other databases:

Visit YGL113W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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