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YGL062W / PYC1



Section 1: Phenotypes.
Gene-drug relationships for YGL062W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGL062W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for PYC1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 7.05673 0.00044165
atorvastatin 125 uM 3.91399 0.00014586
tryptanthrin 250 uM 3.40335 0.00090327
dmso 4% 4 uM 3.32765 0.00085385
semustine 62.5 uM 3.14817 0.0014263
quinacrine hydrochloride 1000 uM 3.1339 0.0014848
lovastatin 154.5 uM 3.03883 0.0019358
naringenin 1000 uM 2.56846 0.0067261
no drug minimal media 0 2.56249 0.025247
sulfanilamide 62.5 uM 2.45954 0.0088232

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for PYC1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 52.2054 2.4379e-08
synthetic complete for BY4743 0 36.2238 1.5093e-07
l-dopa 12.5 ug/ml 29.1756 < 1e-12
synthetic complete for BY4743 0 18.3136 4.463e-06
synthetic complete for BY4743 0 17.4049 5.7369e-06
synthetic complete for BY4743 0 13.0748 0.00048313
37 degrees C 0 10.1557 7.6764e-11
synthetic complete for BY4743 0 8.40489 3.3208e-05
nocodazole 10 ug/ml 8.15436 9.3239e-08
mncl2 2 mM 7.93087 1.539e-09

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YGL062W

Top 10 functional gene interactors with YGL062W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with PYC1 by heterozygous co-sensitivity:

Query Interactor Correlation
PYC1 PRD1 0.56895
PYC1 YGL231C 0.54658
PYC1 CUP2 0.54557
PYC1 SNT2 0.54529
PYC1 YCR023C 0.54323
PYC1 SPG1 0.54268
PYC1 ALK1 0.541
PYC1 YBL094C 0.52858
PYC1 YGL159W 0.52217
PYC1 YPR146C 0.52113

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with PYC1 by homozygous co-sensitivity:

Query Interactor Correlation
PYC1 SPS2 0.57851
PYC1 MIC14 0.56631
PYC1 YPR1 0.55899
PYC1 SWE1 0.53862
PYC1 YOS9 0.51152
PYC1 FUS2 0.49019
PYC1 TWF1 0.48848
PYC1 PHO5 0.48825
PYC1 YBR204C 0.48375
PYC1 YPL113C 0.45829

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YGL062W

Other databases:

Visit YGL062W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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