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YGL045W / RIM8



Section 1: Phenotypes.
Gene-drug relationships for YGL045W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGL045W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RIM8 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
caspofungin 10 nM 5.66374 4.3281e-07
bufexamac 1000 uM 5.52931 6.8876e-07
bufexamac 1000 uM 5.52406 7.0136e-07
caspofungin 10 nM 5.18816 2.2202e-06
tryptanthrin 250 uM 4.45579 4.793e-05
alverine citrate 500 uM 4.28792 0.025159
methotrexate 500 uM 4.28209 7.8785e-05
caspofungin 10 nM 4.11647 7.7059e-05
cloxyquin 15.6 uM 3.9672 0.00012349
nacl 700 mM 3.89172 0.00023715

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RIM8 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
k2cr2o7 125 uM 25.9109 < 1e-12
mpp+ 250 ug/ml 25.1662 < 1e-12
rapamycin 4.88 nM 24.6215 < 1e-12
wiskostatin 29 uM 24.5283 < 1e-12
rapamycin 6 nM 23.1568 < 1e-12
mms 0.002 % 17.3339 0.0016558
mms 0.002 % 16.9634 < 1e-12
hydroxyurea 50000 uM 16.5193 < 1e-12
fk506 0.05 ug/ml 16.5019 < 1e-12
tryptanthrin 250 uM 16.4275 < 1e-12

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YGL045W

Top 10 functional gene interactors with YGL045W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RIM8 by heterozygous co-sensitivity:

Query Interactor Correlation
RIM8 RIM8_p 0.61864
RIM8 YER137C 0.48652
RIM8 YER128W 0.45637
RIM8 SAK1 0.43357
RIM8 STP22 0.42216
RIM8 YER134C 0.40548
RIM8 SDS23 0.3937
RIM8 YER184C 0.39339
RIM8 FTR1 0.3894
RIM8 IAH1 0.38925

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with RIM8 by homozygous co-sensitivity:

Query Interactor Correlation
RIM8 RIM8_p 0.93824
RIM8 RIM21 0.92087
RIM8 RIM20 0.91884
RIM8 RIM13 0.90651
RIM8 RIM101 0.89151
RIM8 YGR122W 0.88549
RIM8 RIM9 0.86767
RIM8 DFG16 0.84733
RIM8 CHS5 0.64811
RIM8 STP22 0.62261

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YGL045W

Other databases:

Visit YGL045W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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