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Yeast Fitness

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YGL040C / HEM2

Section 1: Phenotypes.
Gene-drug relationships for YGL040C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGL040C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for HEM2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 3.91 uM 7.96693 2.1466e-09
bufexamac 1000 uM 3.66777 0.00031118
clotrimazole 1 uM 3.61288 0.00036736
bufexamac 1000 uM 3.58275 0.0004022
atorvastatin 125 uM 3.47584 0.00055317
benomyl 13.8 uM 2.9886 0.015248
benomyl 6.9 uM 2.54143 0.025902
nocodazole 6.9 uM 2.4906 0.02756
lovastatin 77.2 uM 2.46206 0.0087687
lovastatin 62.5 uM 2.34984 0.011517

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YGL040C

Top 10 functional gene interactors with YGL040C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with HEM2 by heterozygous co-sensitivity:

Query Interactor Correlation
HEM2 GPR1 0.60167
HEM2 GVP36 0.5936
HEM2 YMR290W-A 0.56961
HEM2 RPC31 0.56693
HEM2 YGL132W 0.54917
HEM2 GLE1 0.53776
HEM2 MPS2 0.52738
HEM2 VRP1 0.51804
HEM2 DST1 0.50119
HEM2 LIP5 0.50065

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YGL040C

Other databases:

Visit YGL040C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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