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Yeast Fitness
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YGL035C / MIG1



Section 1: Phenotypes.
Gene-drug relationships for YGL035C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGL035C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for MIG1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
5-fluorouracil 38.5 uM 2.82465 0.0061021
benomyl 6.9 uM 1.65584 0.079329
nocodazole 6.9 uM 1.6081 0.084363
benomyl 13.8 uM 1.59346 0.085969
5-fluorouracil 19.2 uM 1.58204 0.066602
floxuridine 3.37 uM 1.31233 0.10396
tunicamycin 0.15 uM 0.636694 0.27616
fenpropimorph 1.65 nM 0.356767 0.36791
5-fluorouracil 38.5 uM 0.315442 0.38258
benomyl 3.4 uM 0.293052 0.39063

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for MIG1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
rapamycin 9 nM 30.4636 3.8852e-05
allyl disulfide 0.06 % 27.6233 < 1e-12
wiskostatin 29 uM 26.435 < 1e-12
rapamycin 6 nM 26.2618 < 1e-12
rapamycin 4.88 nM 21.8158 < 1e-12
fk506 200 uM 21.3068 < 1e-12
rapamycin 9 nM 20.4256 0.0011942
fk506 100 uM 18.4078 < 1e-12
zncl2 1875 uM 17.9957 < 1e-12
fk506 0.05 ug/ml 17.5702 < 1e-12

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YGL035C

Top 10 functional gene interactors with YGL035C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with MIG1 by heterozygous co-sensitivity:

Query Interactor Correlation
MIG1 MET22 0.89172
MIG1 YPT35 0.86593
MIG1 GSH2 0.71512
MIG1 SPC3 0.70918
MIG1 BUD3 0.64989
MIG1 YPL041C 0.64899
MIG1 YGL036W 0.6376
MIG1 NYV1 0.63453
MIG1 PDH1 0.62254
MIG1 YOR139C 0.61886

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with MIG1 by homozygous co-sensitivity:

Query Interactor Correlation
MIG1 FUR4 0.60735
MIG1 TPK1 0.56134
MIG1 YBR292C 0.55203
MIG1 QRI5 0.53279
MIG1 YIL158W 0.53163
MIG1 JJJ2 0.50129
MIG1 YCR085W 0.4961
MIG1 VPS30 0.49522
MIG1 YBR300C 0.49267
MIG1 SNL1 0.49141

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YGL035C

Other databases:

Visit YGL035C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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