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Yeast Fitness

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YGL030W / RPL30

Section 1: Phenotypes.
Gene-drug relationships for YGL030W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGL030W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPL30 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cantharidin 250 uM 45.267 0.00024383
cantharidin 250 uM 41.4489 0.00029078
cantharidin 250 uM 39.7955 0.00031542
cantharidin 250 uM 37.5 0.00035518
cantharidin 250 uM 33.5455 0.00044374
cantharidin 250 uM 26.625 0.00070384
cantharidin 250 uM 12.4261 0.003207
hgcl2 7.81 uM 2.5244 0.0083733
cuso4 10000 uM 2.3957 0.011305
methotrexate 250 uM 2.38591 0.010559

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YGL030W

Top 10 functional gene interactors with YGL030W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with RPL30 by heterozygous co-sensitivity:

Query Interactor Correlation
RPL30 RPL5 0.63024
RPL30 YDR417C 0.60422
RPL30 RPL43A 0.57385
RPL30 RPL23B 0.57154
RPL30 RPL6A 0.56591
RPL30 RPL20B 0.56182
RPL30 RPL20A 0.55843
RPL30 RPL34B 0.55812
RPL30 RPL34A 0.55454
RPL30 RPL14A 0.5497

More... (click to see all interactions)

Enriched GO terms of interactors

Homozygous co-fitness interactions

[No homozygous results.]

External information about YGL030W

Other databases:

Visit YGL030W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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