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Yeast Fitness
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YGL026C / TRP5



Section 1: Phenotypes.
Gene-drug relationships for YGL026C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGL026C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for TRP5 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
ID 697443 0.95 uM 10.901 < 1e-12
cantharidin 250 uM 8.11139 0.0074304
fk506 0.05 ug/ml 4.55019 3.6537e-05
rotenone 250 uM 3.27955 0.0012558
20 degrees C 0 3.01265 0.0020809
telomerase inhibitor ix (Biomol) 500 uM 2.86789 0.0036277
miconazole 50 nM 2.72391 0.0075089
clotrimazole 2 uM 2.3893 0.010473
cantharidin 200 uM 2.36348 0.012172
monastrol 100 uM 2.10771 0.02149

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for TRP5 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 41.4403 6.229e-10
synthetic complete for BY4743 0 40.0736 0.00031106
synthetic complete for BY4743 0 35.5424 1.6591e-07
synthetic complete for BY4743 0 35.1663 1.7494e-07
synthetic complete for BY4743 0 34.0021 2.0689e-07
synthetic complete for BY4743 0 30.7142 3.4329e-07
synthetic complete for BY4743 0 27.621 5.1095e-06
synthetic complete for BY4743 0 25.4524 1.8457e-08
synthetic complete for BY4743 0 25.196 1.9799e-08
synthetic complete for BY4743 0 24.5432 7.414e-05

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YGL026C

Top 10 functional gene interactors with YGL026C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with TRP5 by heterozygous co-sensitivity:

Query Interactor Correlation
TRP5 YLR407W 0.66489
TRP5 TKL1 0.65382
TRP5 HOM3 0.6023
TRP5 CSH1 0.59813
TRP5 PLB1 0.57168
TRP5 SUB1 0.57158
TRP5 CSE4 0.5713
TRP5 ALG3 0.5692
TRP5 FMS1 0.56874
TRP5 RAD33 0.56134

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with TRP5 by homozygous co-sensitivity:

Query Interactor Correlation
TRP5 YDR008C 0.51624
TRP5 PHM6 0.49721
TRP5 TRP1 0.49375
TRP5 EMI2 0.46631
TRP5 TRP4 0.46486
TRP5 TRP2 0.46436
TRP5 ARO2 0.44784
TRP5 TOS1 0.43874
TRP5 TRP3 0.43432
TRP5 GPX2 0.4264

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YGL026C

Other databases:

Visit YGL026C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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