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Yeast Fitness
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YGL017W / ATE1



Section 1: Phenotypes.
Gene-drug relationships for YGL017W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGL017W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ATE1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
dyclonine 500 uM 4.5875 0.00031214
cantharidin 250 uM 3.92622 0.029586
pyrithione zinc 1.95 uM 3.86523 0.00016976
no drug minimal media 0 3.57049 0.0080177
no drug minimal media 0 3.18535 0.012196
lovastatin 77.2 uM 2.887 0.00293
miconazole 50 nM 2.54813 0.010742
dmso 4% 4 uM 2.47718 0.0084478
alverine citrate 500 uM 2.29774 0.013037
ketoconazole 1 uM 2.28278 0.013506

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for ATE1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
phosphatase inhibitor 3 uM 5.69897 1.0599e-06
synthetic complete for BY4743 0 5.07479 0.018353
synthetic complete for BY4743 0 4.98884 0.0037749
synthetic complete for BY4743 0 3.18396 0.024971
mechlorethamine 62.5 uM 3.1005 0.045088
benomyl 10 ug/ml 2.55714 0.041711
mechlorethamine 62.5 uM 2.53166 0.04265
ID 632839 62.5 uM 2.47715 0.0091872
isoleucine dropout 0 2.39527 0.014199
lysine dropout 0 2.33439 0.01605

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YGL017W

Top 10 functional gene interactors with YGL017W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ATE1 by heterozygous co-sensitivity:

Query Interactor Correlation
ATE1 FOX2 0.56722
ATE1 NIT3 0.56231
ATE1 SPG1 0.55091
ATE1 YBL048W 0.54876
ATE1 COX8 0.53186
ATE1 PCL9 0.51313
ATE1 REV1 0.50352
ATE1 YOL046C 0.50121
ATE1 CAR2 0.49546
ATE1 YPL191C 0.48784

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with ATE1 by homozygous co-sensitivity:

Query Interactor Correlation
ATE1 DBP1 0.75287
ATE1 PDR10 0.74665
ATE1 YHR138C 0.74093
ATE1 MDH1 0.72785
ATE1 DAL2 0.72735
ATE1 PUF2 0.67894
ATE1 YHR125W 0.67484
ATE1 PRM8 0.67269
ATE1 RNH1 0.66307
ATE1 YJR020W 0.65843

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YGL017W

Other databases:

Visit YGL017W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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