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Yeast Fitness

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YGL006W / PMC1

Section 1: Phenotypes.
Gene-drug relationships for YGL006W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YGL006W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for PMC1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 1.08497 0.16373

More... (click to see all Heterozygous data)

Homozygous knockout:

Top 10 sensitivity-inducing conditions for PMC1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
sorbitol 1.5e+06 uM 8.83146 1.3188e-09
sorbitol 1 M 7.16664 1.3752e-08
acetic acid 50 uM 5.72276 9.8695e-07
synthetic complete for BY4743 0 4.68831 0.0011195
synthetic complete for BY4743 0 3.23749 0.011507
sorbitol 1.5e+06 uM 3.15793 0.0028721
allyl sulfide 0.12 % 2.84302 0.0037535
ph4 7.5 2.83375 0.0055049
minimal media 0 2.78889 0.0048811
nacl 700 uM 2.69068 0.005488

More... (click to see all Homozygous data)

Section 2: Co-fitness interactions.
Gene-gene relationships for YGL006W

Top 10 functional gene interactors with YGL006W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

[No heterozygous results.]
Homozygous co-fitness interactions

Top 10 interactors with PMC1 by homozygous co-sensitivity:

Query Interactor Correlation
PMC1 YGR053C 0.59994
PMC1 YMR141C 0.58612
PMC1 YDL177C 0.57905
PMC1 YGR021W 0.55678
PMC1 RGM1 0.55429
PMC1 TIR2 0.54033
PMC1 YOR121C 0.5395
PMC1 ERP6 0.53581
PMC1 YGR067C 0.53335
PMC1 MKT1 0.52829

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None

External information about YGL006W

Other databases:

Visit YGL006W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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