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Yeast Fitness
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YFR041C / ERJ5



Section 1: Phenotypes.
Gene-drug relationships for YFR041C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YFR041C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ERJ5 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
dmso 4% 4 uM 5.44161 9.3176e-07
cantharidin 250 uM 3.33773 0.03962
5-fluorouracil 125 uM 3.19255 0.0012581
nocodazole 6.9 uM 3.17434 0.012347
benomyl 6.9 uM 3.07339 0.013838
benomyl 13.8 uM 3.06172 0.014023
alverine citrate 500 uM 2.97932 0.0022803
spironolactone 500 uM 2.60875 0.0060734
methotrexate 125 uM 2.52757 0.0083108
amphotericin b 0.31 uM 2.47855 0.0084192

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for ERJ5 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
hydroxyurea 50000 uM 34.3598 < 1e-12
hydroxyurea 100000 uM 33.3217 < 1e-12
hydroxyurea 50000 uM 13.5739 < 1e-12
hydroxyurea 200000 uM 12.5204 1.2702e-10
hydroxyurea 100000 uM 8.89144 2.6372e-08
wiskostatin 29 uM 6.61847 6.8532e-08
synthetic complete for BY4743 0 4.80563 0.0085766
methotrexate 250 uM 3.20298 0.0017881
sorbitol 1 M 3.1009 0.0019318
methotrexate 250 uM 3.05218 0.0025916

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YFR041C

Top 10 functional gene interactors with YFR041C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ERJ5 by heterozygous co-sensitivity:

Query Interactor Correlation
ERJ5 DOC1 0.66852
ERJ5 SPT2 0.64201
ERJ5 TMA16 0.61816
ERJ5 SPC19 0.61453
ERJ5 VPS64 0.60592
ERJ5 YNL170W 0.60394
ERJ5 YDR222W 0.59742
ERJ5 ARG82 0.59253
ERJ5 KRR1 0.58875
ERJ5 ODC2 0.5837

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with ERJ5 by homozygous co-sensitivity:

Query Interactor Correlation
ERJ5 YFR039C 0.67157
ERJ5 YJL027C 0.58048
ERJ5 YJL049W 0.46522
ERJ5 YSY6 0.4235
ERJ5 YLR104W 0.40958
ERJ5 BPT1 0.39444
ERJ5 YML034C-A 0.38752
ERJ5 GLO4 0.3744
ERJ5 GSH1 0.35516
ERJ5 KAP122 0.34718

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YFR041C

Other databases:

Visit YFR041C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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