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YFR037C / RSC8

Section 1: Phenotypes.
Gene-drug relationships for YFR037C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YFR037C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RSC8 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 3.91 uM 15.5333 < 1e-12
thiabendazole 250 uM 13.9167 < 1e-12
paraquat 2000 uM 13.5589 < 1e-12
paraquat 5000 uM 12.2956 < 1e-12
paraquat 2000 uM 10.8164 < 1e-12
papuamide b 0.37 ug/ml 10.3029 5.4342e-12
paraquat 2000 uM 10.1216 8.4265e-12
cantharidin 250 uM 8.27531 0.0071452
sodium sulfate 625 uM 7.85315 2.9238e-09
resveratrol 2000 uM 7.57959 6.1849e-09

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YFR037C

Top 10 functional gene interactors with YFR037C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with RSC8 by heterozygous co-sensitivity:

Query Interactor Correlation
RSC8 RSC9 0.71736
RSC8 RSC58 0.71263
RSC8 VPS65 0.50352
RSC8 ARP9 0.50193
RSC8 ARP7 0.50134
RSC8 SFH1 0.49918
RSC8 NPL6 0.47096
RSC8 YLR358C 0.44333
RSC8 YCR006C 0.43715
RSC8 FKS1 0.43024

More... (click to see all interactions)

Enriched GO terms of interactors

Homozygous co-fitness interactions

[No homozygous results.]

External information about YFR037C

Other databases:

Visit YFR037C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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