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Yeast Fitness
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YFR031C-A / RPL2A



Section 1: Phenotypes.
Gene-drug relationships for YFR031C-A
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YFR031C-A deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPL2A Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 5.6597 1.4568e-06
methotrexate 500 uM 5.09998 7.4291e-06
5-fluorouracil 38.5 uM 5.04634 5.9602e-05
latrunculin 3.91 uM 4.92144 1.2483e-05
doxorubicin 62.5 uM 4.30333 4.231e-05
methotrexate 500 uM 4.14836 0.00011522
methotrexate 500 uM 4.03027 0.00016083
metergoline 250 uM 3.96669 0.00012369
latrunculin 6.25 uM 3.79056 0.00080219
clotrimazole 1 uM 3.68228 0.00029777

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RPL2A Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 7.32207 1.2675e-05
synthetic complete for BY4743 0 5.98655 0.0046657
synthetic complete for BY4743 0 5.61088 0.00011214
norcantharidin 2500 uM 4.67947 2.2276e-05
synthetic complete for BY4743 0 4.17624 0.00094951
chemdiv 246 62 uM 3.78655 0.00029717
potassium disulfite 2500 uM 3.70747 0.00080581
tryptophan dropout 0 3.35771 0.0036351
synthetic complete for BY4743 400 uM 3.06124 0.0035337
mechlorethamine 62.5 uM 3.0501 0.0026048

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YFR031C-A

Top 10 functional gene interactors with YFR031C-A. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RPL2A by heterozygous co-sensitivity:

Query Interactor Correlation
RPL2A YPD1 0.29226
RPL2A MMS4 0.2642
RPL2A ASI3 0.24465
RPL2A CWC2 0.24247
RPL2A YFR011C 0.23742
RPL2A YNR024W 0.23026
RPL2A YFL054C 0.22953
RPL2A OYE3 0.22533
RPL2A SLD5 0.22524
RPL2A YGK3 0.2241

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with RPL2A by homozygous co-sensitivity:

Query Interactor Correlation
RPL2A RPL27B 0.76413
RPL2A YDL063C 0.73084
RPL2A RPL17B 0.71355
RPL2A RPL23B 0.70145
RPL2A RPL33B 0.68736
RPL2A RPL36A 0.6839
RPL2A YDL062W 0.68345
RPL2A RPL9B 0.67336
RPL2A NOP12 0.67101
RPL2A RPP2A 0.66612

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YFR031C-A

Other databases:

Visit YFR031C-A in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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